The history of hallucinogenic substance use stretches back thousands of years across virtually every human culture, where these substances were often integrated into religious, spiritual, and healing practices. Indigenous communities throughout the Americas, Africa, and Asia developed sophisticated ceremonial contexts for the use of naturally occurring hallucinogens such as psilocybin mushrooms, ayahuasca, peyote, and iboga. These traditional uses were typically characterized by careful preparation, community supervision, and integration of the experience into broader spiritual or therapeutic frameworks. The disconnect between these traditional ceremonial uses and modern recreational consumption patterns has created much of the complexity surrounding contemporary hallucinogen addiction.