Self-Organized 3D Tissue Patterns: Fundamentals, Design, and Experiments
About this ebook
This book investigates the 3D-pattern formation and evolution mechanism in multipotent cells embedded in 3D semi-synthetic hydrogels and the control methodology for self-organized patterns. The authors theoretically and experimentally demonstrate several types of topological 3D-pattern formation by cells in a 3D matrix in vitro, which can be modeled and predicted by mathematical models based on the reaction-diffusion dynamics of various chemical, physical, and mechanical cues. The study, focused on the 3D pattern formation of cells, provides (i) a unique perspective for understanding the self-organized 3D tissue structures based on Turing instability, (ii) the scheme for rationally controlling the cellular self-organization via exogenous factors or tailored inner interfaces inside hydrogels, and (iii) the elaborate and sophisticated regulating method for tuning collective cellular behaviors in 3D matrices.
About the author
Xiaolu Zhu is Associate Professor at Hohai University, China. He graduated from Southeast University, China, in 2007 and obtained a PhD in 2014. He worked as a research scholar at the University of California, Los Angeles, from 2011 to 2013. His work is currently focused on understanding and controlling self-organized 3D patterns of cells and hydrogel-based biofabrication.
Zheng Wang is currently a master’s student at the University of Hong Kong. He obtained his bachelor’s degree from Hohai University in 2020. He is working on the development of the applications of hydrogels in the regulation of cellular behaviors and on the quantification of the relationships between cellular behaviors and the physical properties of the extracellular matrix.
