This report by the World Health Organization explores the future of pandemics and epidemics from a 2022 perspective. It emphasizes the importance of foresight in transitioning from emergency responses to proactive planning for infectious threats. The document outlines key trends and factors influencing pandemics, including social, technological, economic, environmental, and political elements. It advocates for a coordinated global approach, emphasizing trust, solidarity, and equity. The report aims to inspire immediate action, envisioning various future scenarios to enhance pandemic preparedness and resilience. It is intended for policymakers, public health authorities, and stakeholders involved in health and pandemic planning.