Monoclonal Antibodies in Cancer
Stewart Sell · Ralph Reisfeld
Dec 2012 · Contemporary Biomedicine Book 6 · Springer Science & Business Media
Ebook
428
Pages
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About this ebook
References -- 14 Monoclonal Antibodies to Renal Cancer Markers -- 1. Introduction -- 2. Mab S4 -- 3. Mab S22 -- 4. Mab S23 -- 5. Mab S6 -- 6. Use as Markers of Proximal Tubular Cells -- 7. Ability to Discriminate Renal from Nonrenal Cancers -- 8. Subclassification of Renal Cancer -- 8.1. gp/20nr -- 8.2. Subclassification of gp120nr+ Renal Cancers -- 9. Correlation of Antigenic Phenotypes and Clinical Parameters -- 10. Summary -- References -- 15 Immunochemistry of Human Teratocarcinoma Stem Cells -- 1. Introduction -- 2. Stem Cells of Human Teratocarcinomas -- 2.1. Human Embryonal Carcinoma Cells -- 2.2. Surface Markers of Human EC Cells -- 2.3. Intermediate Filaments -- 3. Markers of Differentiation -- 3.1. The Nature of Differentiation -- 3.2. The Disappearance of EC Cell Markers -- 3.3. The Appearance of New Cell Markers -- 4. Conclusions -- References -- 16 Use of Monoclonal Antibodies in Neurobiology and Neurooncology -- 1. Introduction -- 2. Markers of Central and Peripheral Nervous System (PNS) Tumors Defined by Mabs -- 2.1. Biochemically Defined Markers -- 2.2. Shared Nervous System--Lymphoid Cell Markers -- 2.3. Shared Neuroectodermal--Oncofetal Markers -- 2.4. Putative Tumor-Restricted Markers -- 2.5. Markers of Interest Defined in Animal Model Systems -- 3. Current and Prospective Use of Marker-Mab Systems -- 3.1. The Problem of Antibody Localization and Delivery -- 3.2. The Problem of Antigenic Heterogeneity -- 3.3. Current Use of Single Marker--Mab Systems -- 3.4. The Use of Mab Panels -- 4. Summary and Prospects -- References -- 17 Human Monoclonal Antibodies: Humoral Immune Response in Patients with Cancer -- 1. Introduction -- 1.1. Serological Evidence of Tumor Immunity in Humans -- 1.2. Clinical Evidence of Tumor Immunity in Humans -- 1.3. In Vivo Applications of Human Monoclonal Antibodies -- 2. Approaches to the Generation of Human Monoclonal Antibodies -- 2.1. Immortalization of B Lymphocytes by Epstein-Barr Virus -- 2.2. Strategies Using the Hybridoma Technology -- 3. Further Experim.
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