Placebo Effects in Neurology

·
· Elsevier
eBook
350
Pages
Eligible
This book will become available on 01 December 2025. You will not be charged until it is released.

About this eBook

Placebo Effects in Neurology provides a comprehensive understanding of how placebos work and their impact on specific neurological disorders. Placebo effects occur in both clinical practice and clinical trials. Though primarily used in clinical trials to validate a treatment, their use in clinical practice may have benefits for the doctor-patient relationship, in therapeutic outcome, and in symptom perception. This volume describes the placebo effect in neurology, ranging from psychobiological mechanisms to specific neurological conditions and methodological and ethical issues. Both deceptive and nondeceptive (open-label) placebos are discussed. Placebo effects are discussed for neuropathic pain, Parkinson's disease, myasthenia and fatigue, peripheral neuropathies, migraine, and neuropsychiatric disorders like depression and anxiety. - Reviews placebo effects for individual neurological and psychiatric disorders - Covers benefits in therapeutic outcome, symptom perception, and doctor-patient relationship - Discusses psychobiological mechanisms of how placebos work - Considers minimizing placebo and nocebo effects in clinical trials

About the author

Prof. Fabrizio Benedetti, MD is Professor of Neurophysiology and Human Physiology at the University of Turin Medical School, Italy, and Director of Medicine and Physiology of Hypoxia at Plateau Rosà, Switzerland. He identified the basic mechanisms of placebo and nocebo effects across a number of medical conditions and therapeutic interventions, including pain, Parkinson’s disease, the endocrine system and oxygen-dependent critical life functions. He has been a consultant and advisor at NIH, NIMH, NIDA, NCCAM and at Harvard University since 2000. He is recipient of the 2009 Medical Book Award of the BMA, the 2012 Seymour Solomon Award of the American Headache Society, and the 2015 William S Kroger Award of Behavioral Medicine from the American Society of Clinical Hypnosis. In 2023 he received the Lifetime Achievement Award of the Society for Interdisciplinary Placebo Studies. He is currently on the editorial boards for Current Neuropharmacology and Canadian Jrnl of Pain.

Prof. Aziz Shaibani, MD is clinical Professor of Medicine at Baylor College of Medicine and the director of the Nerve and Muscle Centre of Texas. He is board certified in Neurology, neuromuscular medicine, neurophysiology, electrodiagnostic medicine and clinical neuromuscular pathology. He was president of the Texas Neurological society and VP of the neuromuscular section of the American Academy of Neurology. He has been the principal investigator of 145 clinical trials funded by pharmaceutical companies and NIH. He is on the ed board of Practical neurology and serves as a reviewer for the Lancet, BMJ, Neurology, Neurology genetics, and Muscle and Nerve. He is a past recipient of PROSE and BMA awards for best medical book and has been elected to the list of the “best doctors in America since 2009.

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