Phosphoinositides II: The Diverse Biological Functions
Tamas Balla · Matthias Wymann · John D. York
feb. 2012 · Subcellular Biochemistry Cartea 59 · Springer Science & Business Media
Carte electronică
460
Pagini
reportEvaluările și recenziile nu sunt verificate Află mai multe
Despre această carte electronică
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.
Evaluează cartea electronică
Spune-ne ce crezi.
Informații despre lectură
Smartphone-uri și tablete
Instalează aplicația Cărți Google Play pentru Android și iPad/iPhone. Se sincronizează automat cu contul tău și poți să citești online sau offline de oriunde te afli.
Laptopuri și computere
Poți să asculți cărțile audio achiziționate pe Google Play folosind browserul web al computerului.
Dispozitive eReader și alte dispozitive
Ca să citești pe dispozitive pentru citit cărți electronice, cum ar fi eReaderul Kobo, trebuie să descarci un fișier și să îl transferi pe dispozitiv. Urmează instrucțiunile detaliate din Centrul de ajutor pentru a transfera fișiere pe dispozitivele eReader compatibile.
