Pharmaceutical Salts and Co-crystals
Johan Wouters · Luc Quéré
Nob 2011 · Drug Discovery Series Aklat 16 · Royal Society of Chemistry
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From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book_ entirely dedicated to this emerging class of pharmaceutical compounds_ the outcome of such endeavours into crystal engineering have demonstrated clear impacts on production, marketing and intellectual property protection of active pharmaceutical ingredients (APIs). Indeed, co-crystallization influences relevant physico-chemical parameters (such as solubility, dissolution rate, chemical stability, melting point, hygroscopicity, à) and often offers solids with properties superior to those of the free drug. Combining both reports of the latest research and comprehensive overviews of basic principles, with contributions from selected experts in both academia and industry, this unique book is an essential reference, ideal for pharmaceutical development scientists and graduate students in pharmaceutical science.
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Johan Wouters is Professor at the Department of Chemistry and a Member of the Drug Design Discovery Center at the University of Namur, Belgium. He is also a teacher in general chemistry, crystallography and structure-based drug design and is the author of about 120 papers. Luc Quere is at UCB Pharma.
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