The 'Laboratory Biosafety Manual, Fourth Edition' by the World Health Organization is a comprehensive guide providing essential information on laboratory biosafety. It focuses on the principles and practices necessary to ensure safe handling of biological agents in laboratory settings. The manual covers the selection and use of personal protective equipment (PPE), risk assessment, national and international regulations, and containment measures. It is intended for laboratory personnel, safety officers, and health professionals involved in biosafety and biosecurity. The manual aims to minimize the risk of exposure to biological hazards and prevent inadvertent release of infectious materials, promoting a safe working environment.