Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy

Nanasaheb D. Thorat · Nitesh Kumar

xul. de 2021 · Academic Press

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Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy addresses from a comprehensive and multidisciplinary approach the translational aspects and clinical perspectives of nano-pharmacokinetics using cancer as a model disease. Nano-pharmacokinetics is emerging as an important sub discipline of nanoscience and medical sciences because of the increasing safety issues of nanosystems on living organisms. This book reports the dynamics of nanosystems in living organisms for better understanding of nanotoxicity, pharmacology, biochemistry, physiology and medicine perspectives. It further examines current progress of state-of-the art pharmacokinetics mechanisms, which will be of great help to develop more clinical-oriented nanosystems with a wide safety margin. The book is divided into three sections: the first section focuses on the concept of pharmacokinetics with state-of-the-art Nano-Pharmacokinetics (NPK). The second section looks at the engineering of nanoparticles and pharmacokinetics clinical development. The final section focuses on Nano-Pharmacokinetics and Theranostics, elaborating the basic question of how pharmacokinetics of nanomaterials relate to their end applications such as cancer therapy. Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy will be useful to researchers in the field of nanoparticle based targeted drug delivery including pharmaceutical scientists, material scientists, chemists, nanotechnologists, biomedical scientists, and clinicians. - Includes contributions from highly qualified scientists, regulatory entities, enterprises and medical practitioners to explain the long and inherently multidisciplinary pathway of nano-pharmacokinetics - Describes assessment methods of nano-pharmacokinetics - Examines the interface between nanomedicine and pharmacokinetics to diagnose and treat cancer

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Dr. Nanasaheb Thorat is Principal Investigator funded by the Science Foundation Ireland (SFI) and Irish Research Council (IRC) Pathway Program at the University of Limerick, Ireland. He is also a Marie Curie Visiting Research Scientist at the University of Oxford, UK. He has been deeply engaged in collaborative work with the many eminent scientists from Japan, USA, Germany, Korea, Ireland, India, Poland, Saudi Arabia and Australia. Dr. Thorat has received the European Commission’s innovation Radar “Grand Prix of the Innovation Radar Prize 2020 for developing ground-breaking technology for breast cancer theranostics.

Dr. Nitesh Kumar, M Pharm, PhD is an Assistant Professor from the Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur. Dr. Kumar has published 90 peer reviewed journal articles (total citations – 995 and H-index – 19) and 2 book chapters. He delivered talks and oral presentations at several scientific conferences and received awards for his research contributions. Dr. Kumar has more than 10 years of teaching and research experience and currently guiding and co-guiding 12 PhD students on their thesis work. His research work includes biocompatibility and toxicological evaluation of various drug molecules and biomedical devices namely dialysis catridges, tooth implant and electrical stimulator for glioma treatment. His other research areas are neuroprotection, hepatoprotection and neuropharmacological studies of synthesized and herbal compounds. In addition to his scientific contributions, Dr. Kumar collaborated with several government agencies and industries in India and successfully implemented projects of high impact value with successful research outcomes as principal investigator, lead investigator and co-investigator.

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