Molecular Architecture of Proteins and Enzymes

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· Academic Press
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340
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Ukadiriaji na maoni hayajahakikishwa  Pata Maelezo Zaidi

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Molecular Architecture of Proteins and Enzymes marks the second bilateral conference between China and the United States dealing with Proteins in Biology and Medicine held in Oklahoma City, Oklahoma on June 11-13, 1983. This book compiles presentations and resulting papers focusing on the continued importance of research on proteins that has been enhanced by the technologies of recombinant DNA analysis and monoclonal antibodies. The topics discussed include the kinetics of irreversible modification of enzyme activity; structure and mechanism of dopamine β-hydroxylase; three-dimensional structures of scorpion neurotoxins; and nuclear magnetic resonance for the study of protein structure. The crystallographic studies on insulin and its analogs; T cell control of immunoglobulin synthesis; and dissociation and reassembly of viral capside are also elaborated. This text likewise covers the molecular structure of plasma protease inhibitor genes in man and polymorphism of some serum proteins in the Chinese population. This publication is a good reference for biologists and researchers interested in the molecular architecture of proteins and enzymes.

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Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and Biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University, and Professor and Chair of the Department of Biological Chemistry, University of California Irvine. He presently is Professor of Pharmacology at the University of California, San Diego. He served as president of FASEB, was the founding president of the Protein Society and was the treasurer of the ASBMB. He was the founding editor of Molecular and Cellular Proteomics. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signaling. He has also studied the role of proteolytic processing and N-terminal modification in protein stability and turnover.

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