Microbial Resistance Evolution

Samuel Livingston · AI

2025年2月 · Publifye AS

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""Microbial Resistance Evolution"" explores the escalating challenge of drug-resistant microbes, a critical issue impacting global health and economies. The book delves into the genetic and biochemical mechanisms microbes use to resist antimicrobial drugs, as well as the evolutionary dynamics driving the spread of resistance genes. Did you know that horizontal gene transfer allows microbes to rapidly share resistance traits, accelerating the evolution of drug resistance? Understanding these mechanisms is crucial for developing new drugs and effective infection control strategies.

The book adopts a progressive approach, starting with the basics of microbial genetics and antimicrobial action, before moving into complex evolutionary scenarios. It covers topics like mobile genetic elements, the impact of selective pressures, and specific resistance mechanisms such as enzymatic degradation. The overuse of antibiotics has fueled the selection and proliferation of resistant strains, highlighting the need for antimicrobial stewardship.

The book emphasizes the importance of evolutionary principles in predicting and managing resistance, offering insights valuable to students, researchers, and healthcare professionals alike. The concluding chapters provide a comprehensive overview of antimicrobial resistance and propose strategies for combating it, including novel therapeutics and improved infection control practices. This interdisciplinary approach integrates evolutionary biology, pharmacology, and public health to fully understand the complexities of antimicrobial resistance.