Epithelial—Mesenchymal Interactions in Cancer
Itzhak D. Goldberg · Eliot M. Rosen
mar. 2013 · Experientia: Supplementum 74. knjiga · Birkhäuser
E-knjiga
350
Strani
reportOcene in mnenja niso preverjeni. Več o tem
O tej e-knjigi
The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.
Ocenite to e-knjigo
Povejte nam svoje mnenje.
Informacije o branju
Pametni telefoni in tablični računalniki
Namestite aplikacijo Knjige Google Play za Android in iPad/iPhone. Samodejno se sinhronizira z računom in kjer koli omogoča branje s povezavo ali brez nje.
Prenosni in namizni računalniki
Poslušate lahko zvočne knjige, ki ste jih kupili v Googlu Play v brskalniku računalnika.
Bralniki e-knjig in druge naprave
Če želite brati v napravah, ki imajo zaslone z e-črnilom, kot so e-bralniki Kobo, morate prenesti datoteko in jo kopirati v napravo. Podrobna navodila za prenos datotek v podprte bralnike e-knjig najdete v centru za pomoč.
