Epigenetics in Organ Specific Disorders

Chandra S. Boosani · Ritobrata Goswami

Des 2022 · Translational Epigenetics Kitabu cha 34 · Academic Press

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**Selected for Doody's Core Titles® 2024 in Clinical Genetics**Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth.Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies. - Identifies unique epigenetic mechanisms that occur in normal and disease conditions in each organ, examining differences and similarities - Explores organ specific epigenetic mechanisms to enable drug discovery and development - Features chapter contributions from leading researchers in the field

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Dr. Chandra S. Boosani is an Assistant Professor at the Genetics, Epigenetics & Molecular Biology Lab, within the Department of Translational Research, at the College of Osteopathic Medicine, Pacific Western University School of Health Sciences, CA, U.S.A. His research focuses on developing and testing anticancer proteins, and identifying mechanisms of epigenetic drug action, with emphasis on developing recombinant proteins, drug testing in live mice, and analyzing sequencing data. Dr. Boosani has published in such peer reviewed journals as Seminars in Cancer Biology, Blood, Pharmaceuticals, Gene Regulation and Systems Biology, and Protein Expression and Purification.

Ritobrata Goswami is a Assistant Professor in the School of Bioscience, IIT Kharagpur, West Bengal, India.

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