Biochemistry of Brain

Sudhir Kumar

2013年10月 · Elsevier

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Biochemistry of Brain is a collection of articles dealing with the developments in the biochemistry of the brain. This book gives a comprehensive and critical discussion of important developments in studies concerning the above subject. This text discusses the structure, function, and metabolism of glycosphingolipids, which are related to the study of sphingolipid storage diseases. Inborn defects of metabolism are found in Gaucher's and Fabry's disease, which are characterized by lipid accumulation in the brain. Another paper reviews the chemical and genetics of critically lysosomal hydrolase deficiencies that can cause the storage of sphingolipids. This book then explains the role of myelin basic protein in lipids in vivo that the weak bonding of the protein is not a major component of myelin stability. Another paper discusses the procedures for isolating subfractions of myelin and myelin-related membranes, with some attention given on the alterations in the subfractionation of myelin in pathological hypomyelinating and demyelinating conditions. Another article discusses the biochemical and enzymatic composition of lysosomes and the biosynthesis, intracellular transport, storage, and the degradation of lysosomal constituents. This collection of papers will benefit scientists doing research in microbiology, microchemistry, molecular genetics, and neurochemistry.

作者简介

Dr. Sudhir Kumar is currently working as a Professor and Head of the Department of Biotechnology and Bioinformatics at Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India. He completed his Bachelor’s and Master’s from Panjab University, Chandigarh. He then joined Thapar University, Patiala as a CSIR Fellow and completed his doctorate in Biotechnology. During Ph.D. his work was focused on bioremediation and biofuel production. He joined Department of Chemical and Biological Engineering, South Dakota School of Mines and Technology, USA as a postdoctoral research associate. His research work is focused on biofuels production from food and agricultural waste, bioleaching of precious metals from e-waste and industrial enzymes. He is actively involved in training and educating the students and general public to promote technology extension in the area of biogas from municipal solid waste and agricultural residues. He has worked on various sponsored research projects and at present is working as a PI in three projects with one of the projects focused on Biohydrogen production from Pine needles.