Atg8ylation and its Manifestations
Vojo Deretic
2024 abu. · Cambridge Scholars Publishing
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This book covers the emerging field of membrane atg8ylation in 18 chapters contributed by the world’s best experts. In short, atg8ylation is to membranes what ubiquitylation is to proteins. Both function as homeostatic processes: atg8ylation guards and remodels cellular membranes whereas ubiquitylation does the same for proteins. The downstream manifestations of membrane atg8ylation include canonical autophagy and a plethora of diverse phenomena, known by their colorful acronyms, which are difficult to fit into the autophagy paradigm. The minimal substrate for atg8ylation is a phospholipid hemilayer, but more typically atg8ylation works on intracellular membranes consisting of lipid bilayers. The downstream functions of membrane atg8ylation as a novel homeostatic process and the associated physiology, health and disease states remain to be defined. One of the goals of this book is to promote interest and investigations in this growing field.
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Dr Vojo Deretic is a Distinguished Professor and Departmental Chair at the University of New Mexico School of Medicine, USA, and the Director of the NIH-funded Autophagy, Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence. Dr Deretic received his undergraduate, graduate and postdoctoral education in Belgrade, Paris, and Chicago. Dr Deretic’s main contributions to science come from studies by his team on the role of autophagy in homeostatic processes with emphasis on its immunological functions. Recently, his group has defined the more general principle of atg8ylation of which canonical autophagy is only one of the many biological outputs. This is the fourth book that Dr Deretic has edited or co-edited.
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