Antibody Engineering: Methods and Protocols

· Methods in molecular biology 第 248 冊 · Springer Science & Business Media
3.0
1 則評論
電子書
562
評分和評論未經驗證  瞭解詳情

關於本電子書

The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Köhler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these have become indispensable reagents in biomedical research, while others were developed for novel therapeutic applications. The attractiveness of an- bodies in this regard is obvious—high target specificity, adaptability to a wide range of disease states, and the potential ability to direct the host’s immune s- tem for a therapeutic response. The initial excitement in finding Paul Ehrlich’s “magic bullet,” however, was met with widespread disappointment when it was demonstrated that murine antibodies frequently elicit the human anti-murine an- body (HAMA) response, thus rendering them ineffective and potentially unsafe in humans. Despite this setback, advances in recombinant DNA techniques over the last 15–20 years have empowered the engineering of recombinant antibodies with desired characteristics, including properties to avoid HAMA. The ability to p- duce bulk quantities of recombinant proteins from bacterial fermentation also fueled the design of numerous creative antibody constructs. To date, the United States Food and Drug Administration has approved more than 10 recombinant antibodies for human use, and hundreds more are in the development pipeline. The recent explosion in genomic and proteomic information appears ready to deliver many more disease targets amenable to antibody-based therapy.

評分和評論

3.0
1 則評論

為這本電子書評分

歡迎提供意見。

閱讀資訊

智慧型手機與平板電腦
只要安裝 Google Play 圖書應用程式 Android 版iPad/iPhone 版,不僅應用程式內容會自動與你的帳戶保持同步,還能讓你隨時隨地上網或離線閱讀。
筆記型電腦和電腦
你可以使用電腦的網路瀏覽器聆聽你在 Google Play 購買的有聲書。
電子書閱讀器與其他裝置
如要在 Kobo 電子閱讀器這類電子書裝置上閱覽書籍,必須將檔案下載並傳輸到該裝置上。請按照說明中心的詳細操作說明,將檔案傳輸到支援的電子閱讀器上。