Actin-Binding Proteins and Disease
Cris dos Remedios · Deepak Chhabra
2008年1月 · Protein Reviews 第 8 冊 · Springer Science & Business Media
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Actin is a ubiquitous protein present in high concentrations in virtually all cells. It's assembly and disassembly is modulated by more than 100 actin-binding proteins. These interactions are essential for a variety of important cellular processes including cell division, gene expression and motility.
There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders.
This volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole. Additionally, clinicians will be interested because the book explains the role of cytoskeletal proteins in various diseases, including cancer and immune system disorders.
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