The book adopts a chronological approach, starting with the philosophical underpinnings of the scientific method and falsifiability. It then delves into specific case studies, from the alchemists' fruitless quest for the philosopher's stone to the cold fusion fiasco, detailing the experimental setups, prevailing assumptions, and reasons for failure.
By examining these scientific mistakes, the book offers not only a humorous perspective on science history but also valuable lessons for contemporary scientists and policymakers, emphasizing the importance of critical thinking and rigorous methodologies in scientific discovery.